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نوع الوثيقة : مقال في مجلة دورية 
عنوان الوثيقة :
IQGAP1 in podosomes/invadosomes is involved in the progression of glioblastoma multiforme depending on the tumor status
IQGAP1 in podosomes/invadosomes is involved in the progression of glioblastoma multiforme depending on the tumor status
 
لغة الوثيقة : الانجليزية 
المستخلص : Glioblastoma multiforme (GBM) is the most frequent and aggressive primary brain tumor. GBM is formed by a very heterogeneous astrocyte population, neurons, neovascularization and infiltrating myeloid cells (microglia and monocyte derived macrophages). The IQGAP1 scaffold protein interacts with components of the cytoskeleton, cell adhesion molecules, and several signaling molecules to regulate cell morphology and motility, cell cycle and other cellular functions. IQGAP1 overexpression and delocalization has been observed in several tumors, suggesting a role for this protein in cell proliferation, transformation and invasion. IQGAP1 has been identified as a marker of amplifying cancer cells in GBMs. To determine the involvement of IQGAP1 in the onco-biology of GBM, we performed immunohistochemical confocal microscopic analysis of the IQGAP1 protein in human GBM tissue samples using cell type-specific markers. IQGAP1 immunostaining and subcellular localization was heterogeneous; the protein was located in the plasma membrane and, at variable levels, in nucleus and/or cytosol. Moreover, IQGAP1 positive staining was found in podosome/invadopodia-like structures. IQGAP1+ staining was observed in neurons (Map2+ cells), in cancer stem cells (CSC; nestin+) and in several macrophages (CD31+ or Iba1+). Our results indicate that the IQGAP1 protein is involved in normal cell physiology as well as oncologic processes. 
ردمد : 103-390 
اسم الدورية : International journal of molecular sciences 
المجلد : 18 
العدد : 1 
سنة النشر : 1438 هـ
2017 م 
نوع المقالة : مقالة علمية 
تاريخ الاضافة على الموقع : Sunday, May 28, 2017 

الباحثون

اسم الباحث (عربي)اسم الباحث (انجليزي)نوع الباحثالمرتبة العلميةالبريد الالكتروني
Rotoli DeborahDeborah, Rotoli باحث رئيسيدكتوراه 
Pérez-Rodríguez Natalia DoloresNatalia Dolores, Pérez-Rodríguez باحثدكتوراه 
Morales ManuelManuel, Morales باحثدكتوراه 
Maeso María del CarmenMaría del Carmen, Maeso باحثدكتوراه 
Ávila JulioJulio, Ávila باحثدكتوراه 
Mobasheri AliAli, Mobasheri باحثدكتوراه 

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