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نوع الوثيقة : مقال في مجلة دورية 
عنوان الوثيقة :
pSumo-CD: predicting sumoylation sites in proteins with covariance discriminant algorithm by incorporating sequence-coupled effects into general PseAAC
pSumo-CD: predicting sumoylation sites in proteins with covariance discriminant algorithm by incorporating sequence-coupled effects into general PseAAC
 
لغة الوثيقة : الانجليزية 
المستخلص : Motivation: Sumoylation is a posttranslational modification (PTM) process, in which small ubiquitin-related modifier (SUMO) is attaching by covalent bonds to substrate protein. It is critical to many different biological processes such as replicating genome, expressing gene, localizing and stabilizing proteins; unfortunately, it is also involved with many major disorders including Alzheimer’s and Parkinson’s diseases. Therefore, for both basic research and drug development, it is important to identify the sumoylation sites in proteins. Results: To address such a problem, we developed a predictor called pSumo-CD by incorporating the sequence-coupled information into the general pseudo amino acid composition (PseAAC) and introducing the covariance discriminant (CD) algorithm, in which a bias-adjustment term, which has the function to automatically adjust the errors caused by the bias due to the imbalance of training data, had been incorporated. Rigorous cross-validations indicated that the new predictor remarkably outperformed the existing state-of-the-art prediction method for the same purpose. Availability: For the convenience of most experimental scientists, a user-friendly web-server for pSumo-CD has been established at http://www.jci-bioinfo.cn/pSumo-CD, by which users can easily obtain their desired results without the need to go through the complicated mathematical equations involved. 
ردمد : 1460-2059 
اسم الدورية : Bioinformatics 
المجلد : 32 
العدد : 20 
سنة النشر : 1437 هـ
2016 م 
نوع المقالة : مقالة علمية 
تاريخ الاضافة على الموقع : Wednesday, July 12, 2017 

الباحثون

اسم الباحث (عربي)اسم الباحث (انجليزي)نوع الباحثالمرتبة العلميةالبريد الالكتروني
Jianhua JiaJia, Jianhua باحثدكتوراه 
Liuxia ZhangZhang, Liuxia باحثدكتوراه 
Zi LiuLiu, Zi باحثدكتوراه 
Xuan XiaoXiao, Xuan باحثدكتوراه 
Kuo-Chen ChouChou, Kuo-Chen باحثدكتوراه 

الملفات

اسم الملفالنوعالوصف
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